• To investigate the role of DPP

  2019-08-09

  

  To investigate the role of DPP-4 inhibition in inflammation-induced bone resorption, we evaluated the effect of a DPP-4 inhibitor on LPS-induced osteoclast formation and bone-resorption in vivo. Our results showed that the DPP-4 inhibitor inhibited LPS-induced osteoclast formation and bone resorptio

• br Conclusions br Acknowledgments This

  2019-08-08

  

  Conclusions Acknowledgments This work was supported by a grant from NIH from the National Institutes on Arthritis and Musculoskeletal and Skin Diseases [AR056092]. Introduction Prior exposure to stressors has been consistently associated with the manifestation and/or exacerbation of psychi

• These data indicate that in the

  2019-08-08

  

  These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p

• In BBR was reported to increase LDL receptor LDLR gene

  2019-08-08

  

  In 2004, BBR was reported to increase LDL receptor (LDLR) gene expression by stabilizing LDLR mRNA [4]. Following this report, the same groups conducted additional studies predominantly in HepG2 cells, with similar effects being observed [8], [11], [12], [4]. In addition to LDLR-mediated LDL cholest

• Dehydrogenation by a KSTD is also a crucial step during

  2019-08-08

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during gallaminemsds degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroid deg

• In the present study we identified

  2019-08-08

  

  In the present study, we identified that SDF-1α could significantly elevate the expression of p-P65 in the NF-κB signaling pathway and p-Akt in the PI3K-Akt signaling pathway, while significantly reducing the expression of p-IκB in the NF-κB signaling pathway. AMD3100 and hesperidin antagonized the

• Finally the recent work to

  2019-08-08

  

  Finally, the recent work to define the microcircuitry of the central amygdala and the role of specific cell populations in fear conditioning can stand as a useful model for advances in preclinical alcohol research. To date, the role of the amygdala in alcohol-related behaviors, and reward-related be

• In a cell based functional

  2019-08-08

  

  In a cell-based functional assay, the antagonist properties of were assessed by measuring inhibition of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells. produced a concentration-dependent inhibition of CRF (1nM)-induced cAMP production with an IC va

• We then analyzed Ki proliferation index

  2019-08-08

  

  We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups. By Fisher\'s exact test, both the type 1 versus non-type 1 EWS-FLI1 comparison (P = 0.047; T

• The role of ETB clearing receptors has been studied in

  2019-08-08

  

  The role of ETB clearing receptors has been studied in detail in endothelial cell–specific ETB knock-out mice. In these animals, clearance of an intravenous aa dutp of labeled ET-1 was reduced significantly compared with wild-type controls. Importantly, functioning ETB were retained on all other ce

• In the SUMOylation pathway SCE as an

  2019-08-08

  

  In the SUMOylation pathway, SCE1 as an E2 enzyme has an important role in mediating the conjugation of SUMO to target proteins. The accumulated SUMO conjugates in plants are associated with abiotic stress responses (Castro et al, 2012). We performed a drought stress analysis on WT plants, induced by

• Consistent with previous simulations on the DFG Asp out

  2019-08-07

  Consistent with previous simulations on the DFG-Asp-out/-in interconversion of Abl kinase, we only observe the DFG flip with protonated Asp747 (Shan et al., 2009).

• br A brief history of RBR E s RBR E

  2019-08-06

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains

• FG-4592 br Acknowledgment S A was supported by V Plan

  2019-08-05

  Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G.

• We have performed our MSP analyses as

  2019-08-02

  We have performed our MSP analyses as real-time PCR using SybrGreen (Fig. 2).

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